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Using Maternal CRH Levels to Predict Preterm Delivery There has been much interest in the possibility that elevations of maternal plasma CRH levels may be used to predict women destined to deliver preterm.199 In at least three studies, elevated maternal plasma CRH levels were observed as early as 1416 weeks' gestation among women who delivered preterm, and lower concentrations of CRH were discovered in women who delivered postterm.193, 217, 218, 219 In another study, maternal plasma CRH levels were elevated in preterm labor patients at 2832 weeks' gestation who were destined to deliver within 48 hours.220 More recently, however, serum concentrations of CRH were shown to be not clinically useful for the prediction of preterm delivery among women with symptoms of preterm labor.181 Consequently, it seems unlikely that a single marker will prove to be reliable for predicting a multifactorial condition such as spontaneous preterm labor and delivery
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